Suryadi, Cheng, R.-K., Birkett, E. et al. (2 more authors) (2022) Dynamics and potential significance of spontaneous activity in the habenula. eneuro, 9 (5). ISSN 2373-2822
Abstract
The habenula is an evolutionarily conserved structure of the vertebrate brain that is essential for behavioral flexibility and mood control. It is spontaneously active and is able to access diverse states when the animal is exposed to sensory stimuli. Here we investigate the dynamics of habenula spontaneous activity, to gain insight into how sensitivity is optimized. Two-photon calcium imaging was performed in resting zebrafish larvae at single-cell resolution. An analysis of avalanches of inferred spikes suggests that the habenula is subcritical. Activity had low covariance and a small mean, arguing against dynamic criticality. A multiple regression estimator of autocorrelation time suggests that the habenula is neither fully asynchronous nor perfectly critical, but is reverberating. This pattern of dynamics may enable integration of information and high flexibility in the tuning of network properties, thus providing a potential mechanism for the optimal responses to a changing environment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 Suryadi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
Keywords: | avalanche; criticality; dynamics; habenula; reverberation; spontaneous activity |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 11 Oct 2022 09:41 |
Last Modified: | 10 Feb 2023 14:14 |
Status: | Published |
Publisher: | Society for Neuroscience |
Refereed: | Yes |
Identification Number: | 10.1523/eneuro.0287-21.2022 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:191343 |