Shahbazi, Fatemeh, Esfahani, Mohammad Nasr orcid.org/0000-0002-6973-2205, Jabbari, Masoud et al. (1 more author) (2022) A Molecular Dynamics Model for Biomedical Sensor Evaluation:Nanoscale Numerical Simulation of an Aluminum-Based Biosensor. In: 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022. 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2022, 11-15 Jul 2022 Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS . Institute of Electrical and Electronics Engineers Inc. , GBR , pp. 613-616.
Abstract
Metallic nanostructured-based biosensors provide label-free, multiplexed, and real-time detections of chemical and biological targets. Aluminum-based biosensors are favored in this category, due to their enhanced stability and profitability. Despite the recent advances in nanotechnology and the significant improvement in development of these biosensors, some deficiencies restrict their utilization. Hence a detailed insight into their behavior in different conditions would be crucial, which can be achieved with nanoscale numerical simulation. With this aim, an Aluminum-based biosensor is chosen to be analyzed with the help of all-atom molecular dynamics model (AA-MD), using large-scale atomic/molecular massively parallel simulator (LAMMPS). The surface properties and adsorption process through different flow conditions and various concentration of the target, are investigated in this study. In the future work, the results of this study will be used for developing a predictive model for surface properties of the biosensor. Clinical Relevance - The role of biosensors in clinical applications and early diagnosis is evident. This work provides a model for predicting the binding behavior of the target molecules on the biosensor surface in different conditions. Results demonstrate an increase in the adsorption of ethanol on the biosensor surface of 7% up to 80% with changing the velocity from 0.001
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Funding Information: *Research supported by the department of mechanical, aerospace, and civil engineering, University of Manchester. Publisher Copyright: © 2022 IEEE. |
Keywords: | Aluminum,Biosensing Techniques/methods,Molecular Dynamics Simulation,Nanostructures/chemistry,Nanotechnology |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Electronic Engineering (York) |
Depositing User: | Pure (York) |
Date Deposited: | 16 Sep 2022 11:00 |
Last Modified: | 27 Feb 2025 09:40 |
Published Version: | https://doi.org/10.1109/EMBC48229.2022.9871498 |
Status: | Published |
Publisher: | Institute of Electrical and Electronics Engineers Inc. |
Series Name: | Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS |
Identification Number: | 10.1109/EMBC48229.2022.9871498 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:191092 |
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Description: A_Molecular_Dynamics_Model_for_Biomedical_Sensor_Evaluation_Nanoscale_Numerical_Simulation_of_an_Aluminum-Based_Biosensor
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