Gevaert, AB, Wood, N, Boen, JRA et al. (11 more authors) (2022) Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition. European Journal of Preventive Cardiology, 29 (17). pp. 2183-2199. ISSN 2047-4873
Abstract
Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Coronary artery disease; DNA methylation; Epigenetic editing; Heart failure; Histone modification; Hypertension; Non-coding RNA; Physical activity; RNA therapeutics |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) MR/S025472/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Sep 2022 12:01 |
Last Modified: | 25 Jun 2023 23:06 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/eurjpc/zwac179 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:191059 |