Jex, N, Chowdhary, A, Thirunavukarasu, S et al. (1 more author) (2022) A case report of refractory angina in a patient with diabetes and apical hypertrophic cardiomyopathy. European Heart Journal: Case Reports, 6 (8). ytac347. ISSN 2514-2119
Abstract
Background:
Using serial imaging over time, this case reviews the natural history of co-morbid Type two diabetes (T2D) and apical hypertrophic cardiomyopathy (HCM) and assesses the potential combined impact on myocardial structure and perfusion.
Case summary:
A 59-year-old patient with concomitant T2D and an apical phenotype of HCM was seen over a 11-year period with a significant burden of anginal chest pain. Chest pain was refractory to anti-anginal medical therapy and persisted at on-going follow-up. Multi-modality imaging demonstrated significant deterioration in coronary microvascular function and increased myocardial scar burden despite unobstructed epicardial coronary arteries.
Discussion:
Comorbidity with T2D and apical HCM resulted in a significant increase in myocardial fibrosis and deterioration in coronary microvascular function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Cardiac magnetic resonance; Case report; Diabetes; Hypertrophic cardiomyopathy |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Biomedical Imaging Science Dept (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 221690/Z/20/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 16 Sep 2022 14:17 |
Last Modified: | 16 Sep 2022 14:17 |
Status: | Published |
Publisher: | Oxford University Press |
Identification Number: | 10.1093/ehjcr/ytac347 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:191058 |