Bayana, ME, Wailes, JS and Marsden, SP orcid.org/0000-0002-2723-8954 (2022) Multicomponent Synthesis of Substituted Pyridines via a Catalytic Intermolecular aza-Wittig/Diels–Alder Sequence. RSC Advances, 12 (40). pp. 26233-26237. ISSN 2046-2069
Abstract
A three-component synthesis of polysubstituted pyridines has been developed, based upon the synthesis of 2-azadienes by a redox-neutral catalytic intermolecular aza-Wittig reaction and their subsequent Diels–Alder reactions. The two-pot process has been demonstrated using a range of aryl and heteroaromatic aldehydes, substituted α,β-unsaturated acids and push–pull enamines, to give rapid access to diverse tri- and tetrasubstituted pyridines.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). Published by the Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Sep 2022 14:44 |
Last Modified: | 25 Jun 2023 23:05 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/D2RA05018H |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:190813 |