Estimating the impact of changes in weight and BMI on EQ-5D-3L : a longitudinal analysis of a behavioural group-based weight loss intervention

Abstract

Purpose

To estimate the association between changes in BMI and changes in Health-Related Quality of Life (EQ-5D-3L).

Methods

The WRAP trial was a multicentre, randomised controlled trial with parallel design and recruited 1267 adults (BMI ≥ 28 kg/m2). Participants were allocated to Brief Intervention, a Commercial weight management Programme (WW, formerly Weight Watchers) for 12 weeks, or the same Programme for 52 weeks. Participants were assessed at 0, 3, 12, 24, and 60 months. We analysed the relationship between BMI and EQ-5D-3L, adjusting for age and comorbidities, using a fixed effects model. Test for attrition, model specification and missing data were conducted. Secondary analyses investigated a non-symmetric gradient for weight loss vs. regain.

Results

A unit increase in BMI was associated with a − 0.011 (95% CI − 0.01546, − 0.00877) change in EQ-5D-3L. A unit change in BMI between periods of observation was associated with − 0.016 017 (95% CI − 0.0077009, − 0.025086) change in EQ-5D-3L. The negative association was reduced during weight loss, as opposed to weight gain, but the difference was not statistically significant.

Conclusions

We have identified a strong and statistically significant negative relationship between BMI changes and HRQoL. These estimates could be used in economic evaluations of weight loss interventions to inform policymaking.

Clinical trial registration

This trial was registered with Current Controlled Trials, number ISRCTN82857232.

Metadata

Item Type:	Article
Authors/Creators:	Breeze, P. https://orcid.org/0000-0002-4189-8676 Gray, L.A. https://orcid.org/0000-0001-6365-7710 Thomas, C. https://orcid.org/0000-0001-8704-3262 Bates, S.E. Brennan, A. https://orcid.org/0000-0002-1025-312X
Copyright, Publisher and Additional Information:	© 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Keywords:	Obesity; Health economics; Quality of life; Weight-loss
Dates:	Published: November 2022 Published (online): 7 July 2022 Accepted: 17 June 2022
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research
Funding Information:	Funder Grant number Medical Research Council MR/R01664X/1/MR/S009868/1
Depositing User:	Symplectic Sheffield
Date Deposited:	26 Aug 2022 11:25
Last Modified:	10 Feb 2023 17:01
Status:	Published
Publisher:	Springer Nature
Refereed:	Yes
Identification Number:	10.1007/s11136-022-03178-z
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:190349

Download

Published Version

Filename: s11136-022-03178-z.pdf

Licence: CC-BY 4.0

CLICK TO DOWNLOAD

CORE (COnnecting REpositories)

Estimating the impact of changes in weight and BMI on EQ-5D-3L : a longitudinal analysis of a behavioural group-based weight loss intervention

Abstract

Metadata

Download

Published Version

Export

Statistics