Archer, L K, Frame, F M, Walker, H F et al. (7 more authors) (2022) ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate. FEBS open bio. ISSN 2211-5463
Abstract
This study aimed to elucidate the role of ELF3, an ETS family member in normal prostate growth and prostate cancer. Silencing ELF3 in both benign prostate (BPH-1) and prostate cancer (PC3) cell lines resulted in decreased colony forming ability, inhibition of cell migration and reduced cell viability due to cell cycle arrest, establishing ELF3 as a cell cycle regulator. Increased ELF3 expression in more advanced prostate tumours was shown by immunostaining of tissue microarrays and from analysis of gene expression and genetic alteration studies. This study indicates that ELF3 functions as part of normal prostate epithelial growth but also as a potential oncogene in advanced prostate cancers.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) > Yorkshire Cancer Research Unit (York) The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Arts and Humanities (York) > History (York) |
Depositing User: | Pure (York) |
Date Deposited: | 23 Aug 2022 14:00 |
Last Modified: | 23 Jan 2025 00:29 |
Published Version: | https://doi.org/10.1002/2211-5463.13417 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/2211-5463.13417 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:190322 |
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Description: FEBS Open Bio - 2022 - Archer - ETS transcription factor ELF3 ESE‐1 is a cell cycle regulator in benign and malignant
Licence: CC-BY 2.5