Kumar, V, Turnbull, WB orcid.org/0000-0002-7352-0360 and Kumar, A (2022) Review on Recent Developments in Biocatalysts for Friedel–Crafts Reactions. ACS Catalysis, 12 (17). pp. 10742-10763. ISSN 2155-5435
Abstract
The Friedel–Crafts (F–C) reaction has been a fundamental pillar of both academic and industrial synthetic organic chemistry since its discovery in 1873. Its success is based on the versatility and applicability of F–C reactions for a wide range of substrates, and there have been an impressive number of publications and patents describing catalytic F–C reaction methods. The asymmetric version of the reaction was discovered about 100 years after the seminal work by Friedel and Crafts and has become a major area of research. While chemical methods with much-improved efficacies and scopes have been discovered, F–C reactions still suffer from limitations. Biocatalysis has the potential to be the best solution to this challenge because of the excellent selectivity (enantio-, chemo-, and regioselectivity) displayed by enzymes. In the last two decades, advancements in molecular biology techniques, bioinformatics, high-throughput screening, directed evolution, and process scale-up have led to biocatalysis becoming a mature field. It is therefore not surprising that researchers around the globe have developed several biocatalysts for asymmetric F–C reactions. Herein, we review recent developments in the design and use of catalytic and stereoselective strategies for performing the asymmetric F–C reactions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 American Chemical Society. This is an author produced version of an article published in ACS Catalysis. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | biocatalysis, asymmetric Friedel−Crafts reactions, artificial metalloenzymes, DNA-based catalysts, acyltransferases, methyltransferases, monoamine-oxidases, expanded genetic code methods |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 23 Aug 2022 15:30 |
Last Modified: | 17 Aug 2023 00:13 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Identification Number: | 10.1021/acscatal.2c01134 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:190174 |