Duckett, Simon B. orcid.org/0000-0002-9788-6615, Tickner, Benjamin, Angelovski, Goran et al. (1 more author) (2022) In Situ Ternary Adduct Formation of Yttrium Polyaminocarboxylates Leads to Small Molecule Capture and Activation. Chemistry : A European Journal. e202201780. ISSN 1521-3765
Abstract
In this work the chemistry of yttrium complexes is exploited for small molecule capture and activation. Nuclear magnetic resonance (NMR) and density functional theory (DFT) studies were used to investigate the in situ formation of solution state ternary yttrium-acetate, yttrium-bicarbonate, and yttrium-pyruvate adducts with a range of polyaminocarboxylate chelates. These studies reveal that [Y(DO3A)(H2O)2] (H3DO3A – 1,4,7,10-tetraazacyclododecane-1,4,7-tricarboxylic acid) and [Y(EDTA)(H2O)2] (H4EDTA – ethylenediaminetetraacetic acid) are able to form ternary adducts with bicarbonate and pyruvate. In the latter, unusual decarboxylation of pyruvate to form acetic acid and CO2 was observed and further studied using SABRE-hyperpolarised 13C NMR (SABRE – signal amplification by reversible exchange) to provide information about the reaction timescale and lifetime of intermediates involved in this conversion. The work presented demonstrates that yttrium complexes can capture and activate small molecules, which may lead to novel and useful applications of this metal in catalysis and medical imaging.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z MEDICAL RESEARCH COUNCIL (MRC) MR/M008991/1 |
Depositing User: | Pure (York) |
Date Deposited: | 08 Aug 2022 11:10 |
Last Modified: | 26 Nov 2024 00:54 |
Published Version: | https://doi.org/10.1002/chem.202201780 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/chem.202201780 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:189829 |