Ramli, NA, Adam, F, Mohd Amin, KN et al. (2 more authors) (2023) Evaluation of Mechanical and Thermal Properties of Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule. The Canadian Journal of Chemical Engineering, 101 (3). pp. 1219-1234. ISSN 0008-4034
Abstract
The inherent source of gelatin used for commercial hard capsules causes a surging demand on vegetarian capsules. In this work, carrageenan is utilized in preparing hard capsules to meet consumer preferences. Hydroxypropyl methylcellulose (HPMC) was incorporated as a reinforcing agent to improve the low mechanical properties of hard capsules made of carrageenan. HPMC concentration was manipulated from 0.2 w/v% to 1.0 w/v% in the carrageenan matrix. Increasing concentration of HPMC exerts significant effects on the tensile strength and elongation at break, with an improvement of 59.1% and 46.9%, respectively, at the optimized HPMC concentration of 0.8 w/v%. The loop strength of the capsule is also increased by 56.4% with decreasing moisture content. A downfield movement around 3.20 ppm of the carrageenan proton to 3.33 ppm in 1H-NMR spectrum suggests the formation of intermolecular hydrogen bonding between carrageenan and HPMC, which correlates to the results of FTIR and zeta potential. The glass transition of the film is increased from 37.8°C to 65.3°C, showing an upgrade in thermal stability. The film possesses a major mass loss with an activation energy of 64.7 kJ/mol with an increment of 43.4% compared to the control carrageenan. These findings support the conclusion that HPMC enhanced the mechanical properties and thermal stability of the carrageenan film, and the comprehensive analysis of the molecular interaction and decomposition kinetics subsequently may expand the application fields of the carrageenan-HPMC hard capsule as an alternative to gelatin in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is protected by copyright. All rights reserved. This is the peer reviewed version of the following article: Ramli, N.A., Adam, F., Mohd Amin, K.N., M. Nor, A. and Ries, M.E. (2022), Evaluation of Mechanical and Thermal Properties of Carrageenan/Hydroxypropyl Methyl Cellulose Hard Capsule. Can J Chem Eng. Accepted Author Manuscript which has been published in final form at https://doi.org/10.1002/cjce.24595. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
Keywords: | activation energy; carrageenan; hydroxypropylmethyl cellulose; mechanical strength; thermal stability |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Physics and Astronomy (Leeds) > Soft Matter Physics (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Aug 2022 11:04 |
Last Modified: | 06 Aug 2023 00:13 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/cjce.24595 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:189778 |