Saikia, Q, Reeve, H, Alzahrani, A et al. (5 more authors) (2022) VEGFR endocytosis: Implications for angiogenesis. In: Progress in Molecular Biology and Translational Science. Progress in Molecular Biology and Translational Science . Elsevier
Abstract
The binding of vascular endothelial growth factor (VEGF) superfamily to VEGF receptor tyrosine kinases (VEGFRs) and co-receptors regulates vasculogenesis, angiogenesis and lymphangiogenesis. A recurring theme is that dysfunction in VEGF signaling promotes pathological angiogenesis, an important feature of cancer and pro-inflammatory disease states. Endocytosis of basal (resting) or activated VEGFRs facilitates signal attenuation and endothelial quiescence. However, increasing evidence suggest that activated VEGFRs can continue to signal from intracellular compartments such as endosomes. In this chapter, we focus on the evolving link between VEGFR endocytosis, signaling and turnover and the implications for angiogenesis. There is much interest in how such understanding of VEGFR dynamics can be harnessed therapeutically for a wide range of human disease states.
Metadata
Item Type: | Book Section |
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Authors/Creators: |
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Keywords: | Blood vessel; Endothelial cell; Vascular endothelial growth factor; Receptor tyrosine kinase |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Cardiovascular Science (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Aug 2022 10:17 |
Last Modified: | 09 Aug 2022 10:17 |
Status: | Published online |
Publisher: | Elsevier |
Series Name: | Progress in Molecular Biology and Translational Science |
Identification Number: | 10.1016/bs.pmbts.2022.06.021 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:189738 |