Clayton Da Silva, A., Akbar, T.F., Paterson, T.E. et al. (3 more authors) (2022) Electrically controlled click‐chemistry for assembly of bioactive hydrogels on diverse micro‐ and flexible electrodes. Macromolecular Rapid Communications, 43 (23). 2200557. ISSN 1022-1336
Abstract
The seamless integration of electronics with living matter requires advanced materials with programmable biological and engineering properties. Here electrochemical methods to assemble semi-synthetic hydrogels directly on electronically conductive surfaces are explored. Hydrogels consisting of poly (ethylene glycol) (PEG) and heparin building blocks are polymerized by spatially controlling the click reaction between their thiol and maleimide moieties. The gels are grown as conformal coatings or 2D patterns on ITO, gold, and PtIr. This study demonstrates that such coatings significantly influence the electrochemical properties of the metal-electrolyte interface, likely due to space charge effects in the gels. Further a promising route toward engineering and electrically addressable extracellular matrices by printing arrays of gels with binary cell adhesiveness on flexible conductive surfaces is highlighted.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. Macromolecular Rapid Communications published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | click chemistry; electrochemistry; glycosaminoglycans; hydrogels; microelectrodes |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Automatic Control and Systems Engineering (Sheffield) |
Funding Information: | Funder Grant number European Commission - HORIZON 2020 804005 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Aug 2022 09:24 |
Last Modified: | 24 Feb 2023 11:17 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/marc.202200557 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:189490 |