Chen, Y.-M., Zang, L.-S., Koc-Bilican, B. et al. (12 more authors) (2022) Macroporous surgical mesh from a natural cocoon composite. ACS Sustainable Chemistry & Engineering, 10 (18). pp. 5728-5738. ISSN 2168-0485
Abstract
Recently, traditional polymer-based surgical meshes have drawn unwanted attention as a result of host tissue complications arising from infection, biocompatibility, and mechanical compatibility. Seeking an alternative solution, we present a hierarchically structured nanofibrous surgical mesh derived from the naturally woven cocoon of the Japanese giant silkworm, termed MothMesh. We report that it displays nontoxicity, biocompatibility, suitable mechanical properties, and porosity while showing no adverse effect in animal trials and even appears to enhance cell proliferation. Hence, we assert that the use of this natural material may provide an effective and improved alternative to existing synthetic meshes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 American Chemical Society. This is an author-produced version of a paper subsequently published in ACS Sustainable Chemistry and Engineering. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | sustainable material; fibroin; sericin; biocompatibility; surgical mesh; tissue engineering |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 12 Jul 2022 13:55 |
Last Modified: | 25 Apr 2023 00:13 |
Status: | Published |
Publisher: | American Chemical Society (ACS) |
Refereed: | Yes |
Identification Number: | 10.1021/acssuschemeng.1c06941 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:189011 |