Gene of the month: NKX3.1

Abstract

NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.

Metadata

Item Type:	Article
Authors/Creators:	Griffin, J. https://orcid.org/0000-0003-3969-7637 Chen, Y. Catto, J.W.F. https://orcid.org/0000-0003-2787-8828 El-Khamisy, S. https://orcid.org/0000-0003-2721-7763
Copyright, Publisher and Additional Information:	© Author(s) (or their employer(s)) 2022. This is an author-produced version of a paper subsequently published in Journal of Clinical Pathology. Uploaded in accordance with the publisher's self-archiving policy. No commercial re-use.
Dates:	Published: June 2022 Published (online): 7 January 2022 Accepted: 20 December 2021
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Sheffield Teaching Hospitals
Funding Information:	Funder Grant number PATHOLOGICAL SOCIETY OF GREAT BRITAIN AND IRELAND Dr Jon Griffin LISTER INSTITUTE OF PREVENTIVE MEDICINE UNSPECIFIED
Depositing User:	Symplectic Sheffield
Date Deposited:	11 Jul 2022 11:08
Last Modified:	13 Jul 2022 03:52
Status:	Published
Publisher:	BMJ
Refereed:	Yes
Identification Number:	10.1136/jclinpath-2021-208073
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:188934

Download

Accepted Version

Filename: gotm-nkx3.1_v2.pdf

Licence: CC-BY-NC 4.0

CLICK TO DOWNLOAD

CORE (COnnecting REpositories)

Gene of the month: NKX3.1

Abstract

Metadata

Download

Accepted Version

Export

Statistics