Synthetic biology approaches to actinomycete strain improvement

Abstract

Their biochemical versatility and biotechnological importance make actinomycete bacteria attractive targets for ambitious genetic engineering using the toolkit of synthetic biology. But their complex biology also poses unique challenges. This mini review discusses some of the recent advances in synthetic biology approaches from an actinomycete perspective and presents examples of their application to the rational improvement of industrially relevant strains.

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Item Type:	Article
Authors/Creators:	Breitling, Rainer Avbelj, Martina Bilyk, Oksana Carratore, Francesco Del Filisetti, Alessandro Hanko, Erik K.R. Iorio, Marianna Redondo, Rosario Pérez Reyes, Fernando Rudden, Michelle https://orcid.org/0000-0001-9617-087X Severi, Emmanuele (es513@york.ac.uk) Slemc, Lucija Schmidt, Kamila Whittall, Dominic R. Donadio, Stefano García, Antonio Rodríguez Genilloud, Olga Kosec, Gregor De Lucrezia, Davide Petković, Hrvoje Thomas, Gavin https://orcid.org/0000-0002-9763-1313 Takano, Eriko
Copyright, Publisher and Additional Information:	Funding Information: This review was funded through the European Union s Horizon 2020 Research and Innovation Programme under grant agreement number 720793 TOPCAPI Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of FEMS.
Keywords:	Actinobacteria,Actinomycete,Biosynthesis,Biotechnology,Synthetic biology
Dates:	Accepted: 28 May 2021 Published: 31 May 2021
Institution:	The University of York
Academic Units:	The University of York > Faculty of Sciences (York) > Centre for Immunology and Infection (CII) (York) The University of York > Faculty of Sciences (York) > Biology (York)
Funding Information:	Funder Grant number EUROPEAN COMMISSION 720793
Depositing User:	Pure (York)
Date Deposited:	06 Jul 2022 10:50
Last Modified:	07 Apr 2025 23:12
Published Version:	https://doi.org/10.1093/femsle/fnab060
Status:	Published
Refereed:	Yes
Identification Number:	10.1093/femsle/fnab060
Related URLs:	http://www.scopus.com/inward/record.url?...
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:188784

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Synthetic biology approaches to actinomycete strain improvement

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