Das, G, Pallipurath, A orcid.org/0000-0002-9778-5160, Leng, J orcid.org/0000-0001-9790-162X et al. (10 more authors) (2020) Time-Resolved X-ray Phase-Contrast Imaging (XPCI) of Nucleation and Crystal Growth in the Anti-Solvent Crystallization of Lovastatin. [Preprint - ChemRxiv]
Abstract
X-ray phase contrast imaging (XPCI) of anti-solvent crystallization of lovastatin from an acetone/water solution was carried out in a concentric flow mixing device, using water as the anti-solvent. Spinodal decomposition of the solution is observed to give rise to ‘oiled out’ phases that undergo heterogeneous nucleation at the interface with the flowing solution. Heterogeneous nucleation is also observed on the walls of the reactor walls in the form of what appears to be Stranski–Krastanov growth of plate-like crystals. XPCI together with Eulerian video magnification forms a powerful tool for the spatio-temporal analysis, revealing mechanistic details of a non-equilibrium process such as anti-solvent crystallization.
Metadata
Item Type: | Preprint |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number EPSRC (Engineering and Physical Sciences Research Council) EP/R016372/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 May 2024 14:47 |
Last Modified: | 07 May 2024 14:47 |
Identification Number: | 10.26434/chemrxiv.12911168.v1 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188772 |