Ord, J., Fazeli, A. orcid.org/0000-0003-0870-9914 and Watt, P.J. (2022) Brief exposures to conspecific-derived alarm substance are sufficient to induce paternal intergenerational effects in zebrafish. Environmental Biology of Fishes, 105 (6). pp. 741-751. ISSN 0378-1909
Abstract
Paternal intergenerational effects, whereby the father’s environment influences the phenotype of the offspring via molecular (e.g. epigenetic) changes to the sperm, comprise an area of active research in multiple biological contexts. Spermatogenesis is a critical window of sensitivity to environmental changes, such that males at full sexual maturity can acquire, incorporate, and transmit environmental information in spermatozoa. The degree of sensitivity is less clear, and as such previous experimental studies have typically relied on prolonged exposure regimes encapsulating the entire period of spermatogenesis. Here we exposed adult male zebrafish to a model stressor (conspecific-derived alarm substance, AS) in two 20-min episodes timed either shortly before or during the onset of spermatogenesis. There was no clear effect of paternal stress on a behavioural stress response in larval offspring but clear reductions in anxiety-like behaviour in juvenile offspring. Our findings suggest that prolonged exposures may not be required for the induction of measurable intergenerational responses in this popular vertebrate model.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © The Author(s) 2022. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
Keywords: | Zebrafish; Paternal effects; Intergenerational effects; Stress; Thigmotaxis |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) |
Funding Information: | Funder Grant number COST OFFICE COST CA16119 COST OFFICE COST ACTION - FA1201 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 06 Jul 2022 13:18 |
Last Modified: | 10 Feb 2023 14:13 |
Status: | Published |
Publisher: | Springer Science and Business Media LLC |
Refereed: | Yes |
Identification Number: | 10.1007/s10641-022-01289-7 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188693 |
Download
Filename: Ord2022_Article_BriefExposuresToConspecific-de.pdf
Licence: CC-BY 4.0