Steinberg, J., Southam, L., Butterfield, N.C. et al. (15 more authors) (Submitted: 2019) Decoding the genomic basis of osteoarthritis. [Preprint]
Abstract
<jats:title>Abstract</jats:title><jats:p>Osteoarthritis causes pain and functional disability for a quarter of a billion people worldwide, with no disease-stratifying tools nor modifying therapy. Here, we use primary cartilage and synovium from osteoarthritis patients to construct a molecular quantitative trait locus map of gene expression and protein abundance. By integrating data across omics levels, we identify likely effector genes for osteoarthritis-associated genetic signals. We detect pronounced molecular differences between macroscopically intact and highly degenerated cartilage. We identify molecularly-defined patient subgroups that correlate with clinical characteristics, stratifying patients on the basis of their molecular profile. We construct and validate a 7-gene classifier that reproducibly distinguishes between these disease subtypes, and identify potentially actionable compounds for disease modification and drug repurposing.</jats:p>
Metadata
Item Type: | Preprint |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors. Preprint made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 07 Jul 2022 09:08 |
Last Modified: | 07 Jul 2022 09:08 |
Identification Number: | 10.1101/835850 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188636 |