Pederzani, G., Czechowicz, K., Ghorab, N. et al. (5 more authors) (2022) The use of digital coronary phantoms for the validation of arterial geometry reconstruction and computation of virtual FFR. Fluids, 7 (6). 201. ISSN 2311-5521
Abstract
We present computational fluid dynamics (CFD) results of virtual fractional flow reserve (vFFR) calculations, performed on reconstructed arterial geometries derived from a digital phantom (DP). The latter provides a convenient and parsimonious description of the main vessels of the left and right coronary arterial trees, which, crucially, is CFD-compatible. Using our DP, we investigate the reconstruction error in what we deem to be the most relevant way—by evaluating the change in the computed value of vFFR, which results from varying (within representative clinical bounds) the selection of the virtual angiogram pair (defined by their viewing angles) used to segment the artery, the eccentricity and severity of the stenosis, and thereby, the CFD simulation’s luminal boundary. The DP is used to quantify reconstruction and computed haemodynamic error within the VIRTUheartTM software suite. However, our method and the associated digital phantom tool are readily transferable to equivalent, clinically oriented workflows. While we are able to conclude that error within the VIRTUheartTM workflow is suitably controlled, the principal outcomes of the work reported here are the demonstration and provision of a practical tool along with an exemplar methodology for evaluating error in a coronary segmentation process.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
Keywords: | digital phantom; coronary angiography; physiology; fractional flow reserve; computational fluid dynamics; percutaneous coronary intervention |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Funding Information: | Funder Grant number WELLCOME TRUST (THE) 214567/Z/18/Z EUROPEAN COMMISSION - HORIZON 2020 857533 British Heart Foundation TG/19/1/34451 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 29 Jun 2022 15:57 |
Last Modified: | 29 Jun 2022 15:57 |
Status: | Published |
Publisher: | MDPI |
Refereed: | Yes |
Identification Number: | 10.3390/fluids7060201 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188564 |