Lin, Yiyang, Penna, Matthew, Spicer, Christopher D orcid.org/0000-0001-8787-578X et al. (8 more authors) (2021) High-Throughput Peptide Derivatization toward Supramolecular Diversification in Microtiter Plates. ACS Nano. pp. 4034-4044. ISSN 1936-0851
Abstract
The evolution of life on earth eventually leads to the emergence of species with increased complexity and diversity. Similarly, evolutionary chemical space exploration in the laboratory is a key step to pursue the structural and functional diversity of supramolecular systems. Here, we present a powerful tool that enables rapid peptide diversification and employ it to expand the chemical space for supramolecular functions. Central to this strategy is the exploitation of palladium-catalyzed Suzuki-Miyaura cross-coupling reactions to direct combinatorial synthesis of peptide arrays in microtiter plates under an open atmosphere. Taking advantage of this in situ library design, our results unambiguously deliver a fertile platform for creating a set of intriguing peptide functions including green fluorescent protein-like peptide emitters with chemically encoded emission colors, hierarchical self-assembly into nano-objects, and macroscopic hydrogels. This work also offers opportunities for quickly surveying the diversified peptide arrays and thereby identifying the structural factors that modulate peptide properties.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 American Chemical Society |
Keywords: | Hydrogels,Palladium,Peptides |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 27 Jun 2022 15:50 |
Last Modified: | 26 Nov 2024 00:53 |
Published Version: | https://doi.org/10.1021/acsnano.0c05423 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1021/acsnano.0c05423 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188484 |