Arribas Perez, M and Beales, PA orcid.org/0000-0001-9076-9793 (2022) Protein corona alters the mechanisms of interaction between silica nanoparticles and lipid vesicles. Soft Matter, 18 (27). pp. 5021-5026. ISSN 1744-683X
Abstract
The use of nanoparticles (NPs) for biomedical applications implies their delivery into the organism where they encounter biological fluids. In such biological fluids, proteins and other biomolecules adhere to the surface of the NPs forming a biomolecular corona that can alter significantly the behaviour of the nanomaterials. Here, we investigate the impact of a bovine serum albumin corona on interactions between silica nanoparticles (SNPs) of two different sizes and giant lipid vesicles. The formation of the protein corona leads to a significant increase of the hydrodynamic size of the SNPs. Confocal microscopy imaging shows that the protein corona alters the morphological response of vesicles to SNPs. In addition, Laurdan spectral imaging show that the protein corona weakens the effect of SNPs on the lipid packing in the GUV membrane. Our results demonstrate that a protein corona can change the interaction mechanism between nanoparticles and lipid membranes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Physical Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Jun 2022 12:43 |
Last Modified: | 25 Jun 2023 23:01 |
Status: | Published |
Publisher: | Royal Society of Chemistry (RSC) |
Identification Number: | 10.1039/d2sm00739h |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:188042 |