Scrimshire, Ashley orcid.org/0000-0002-7784-5891, Fairhurst, Caroline Marie orcid.org/0000-0003-0547-462X, McDaid, Catriona Maria orcid.org/0000-0002-3751-7260 et al. (1 more author) (2021) Effectiveness of pre-operative anaemia screening and increased Tranexamic acid dose policies on outcomes following unilateral primary, elective total hip or knee replacement:a statistical analysis plan for an interrupted time series and regression discontinuity study. F1000research. 224. ISSN 2046-1402
Abstract
Perioperative blood transfusion is associated with poorer postoperative outcomes following hip and knee replacement surgery. Evidence for the effectiveness of some measures aimed at reducing blood transfusions in this setting are limited and often rely on weak pre-post study designs. Quasi-experimental study designs such as interrupted time series (ITS) and regression discontinuity design (RDD) address many of the weaknesses of the pre-post study design. In addition, a priori publication of statistical analysis plans for such studies increases their transparency and likely validity, as readers are able to distinguish between pre-planned and exploratory analyses. As such, this article, written prospective of any analysis, provides the statistical analysis plan for an ITS and RDD study based on a data set of 20,772 primary elective hip and knee replacement patients in a single English NHS Trust. The primary aim is to evaluate the impact of a preoperative anaemia optimisation service on perioperative blood transfusion (within 7 days of surgery) using both ITS and RDD methods. A secondary aim is to evaluate the impact of a policy of increased tranexamic acid dose given at the time of surgery, using ITS methods.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Scrimshire AB et al. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 09 Jun 2022 11:00 |
Last Modified: | 27 Dec 2024 00:21 |
Published Version: | https://doi.org/10.12688/f1000research.22962.2 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.12688/f1000research.22962.2 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:187828 |
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Description: Effectiveness of pre-operative anaemia screening and increased Tranexamic acid dose policies on outcomes following unilateral primary, elective total hip or knee replacement: a statistical analysis plan for an interrupted time series and regression discon
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