Zhang, H, Lianto, P, Li, W et al. (3 more authors) (2022) Associations between liver X receptor polymorphisms and blood lipids: a systematic review and meta-analysis. Steroids, 185. 109057. ISSN 0039-128X
Abstract
Genetic susceptibility to dyslipidaemia remains incompletely understood. The liver X receptors (LXRs), members of the nuclear receptor superfamily of ligand dependent transcription factors, are homeostatic regulators of lipid metabolism. Multiple single nucleotide polymorphisms (SNPs) have been identified previously in the coding and regulatory regions of the LXRs. The aim of this systematic review and meta-analysis was to summarise associations between SNPs of LXRs (α and β isoforms) with blood lipid and lipoprotein traits. Five databases (PubMed, Ovid Embase, Scopus, Web of Science, and the Cochrane Library) were systematically searched for population-based studies that assessed associations between one or more blood lipid/lipoprotein traits and LXR SNPs. Of seventeen articles included in the qualitative synthesis, ten were eligible for meta-analysis. Nine LXRα SNPs and five LXRβ SNPs were identified, and the three most studied LXRα SNPs were quantitatively summarised. Carriers of the minor allele A of LXRα rs12221497 (-115G>A) had higher TG levels than GG homozygotes (0.13 mmol/L; 95%CI: [0.03, 0.23], P=0.01). Heterozygote carriers of LXRα rs2279238 (297C/T) had higher TC levels (0.12 mmol/L; (95%CI: [0.01, 0.23], P=0.04) than either CC or TT homozygotes. For LXRα rs11039155 (-6G>A), no significant differences in blood levels of either TG (P=0.39) or HDL-C (P=0.98) were detected between genotypes in meta-analyses. In addition, there were no strong associations for other SNPs of LXRα and LXRβ. This study provides the evidence of an association between LXRα, but not LXRβ, SNPs and blood-lipid traits.
Systematic review registration: PROSPERO No. CRD42021246158
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. This is an open access article under the terms of the Creative Commons Attribution License (CC-BY-NC-ND 4.0). |
Keywords: | polymorphisms, liver X receptors; blood lipids; cholesterol; triglycerides; atherosclerosis; meta-analysis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 07 Jun 2022 15:17 |
Last Modified: | 25 Feb 2025 14:18 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.steroids.2022.109057 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:187702 |