Ong, A.C.M. orcid.org/0000-0002-7211-5400 and Torra, R. (2022) Can ketogenic dietary interventions slow disease progression in ADPKD : what we know and what we don't. Clinical Kidney Journal, 15 (6). sfac103. pp. 1034-1036. ISSN 2048-8505
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease leading to kidney failure. To date there is no cure for the disease although there is one approved disease modifying therapy, tolvaptan. In this context, a common question that ADPKD patients ask in clinical practice is whether there is anything they can do to slow their disease by modifying their diet or lifestyle. Recent evidence from experimental PKD models has shown the potential benefits of caloric restriction, high water intake and especially ketogenic diets in preserving kidney function. Whether these benefits are translatable to humans remains unknown.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). Published by Oxford University Press on behalf of the ERA. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
Keywords: | ADPKD; disease progression; fasting; GFR; ketogenic diets |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Sheffield Teaching Hospitals |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 17 May 2022 12:48 |
Last Modified: | 24 Nov 2022 15:24 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Refereed: | Yes |
Identification Number: | 10.1093/ckj/sfac103 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:186898 |