Gröschel, M.I., van den Boom, M., Dixit, A. et al. (5 more authors) (2022) Management of childhood MDR-TB in Europe and Central Asia : report of a Regional WHO meeting. International Journal of Tuberculosis and Lung Disease, 26 (5). pp. 433-440. ISSN 1027-3719
Abstract
BACKGROUND: As the WHO European Region has the highest proportion of multidrug-resistant TB (MDR-TB) among total incident TB cases, many children and adolescents are at risk of MDR-TB infection and disease.
METHODS: We performed an electronic survey of clinicians and TB programme personnel who attended the 2020 Regional Consultation on child and adolescent TB organised by the WHO Regional Office. We characterised access to diagnostics and drugs, and practices in the prevention and management of child and adolescent MDR-TB.
RESULTS: Children and adolescents are inconsistently represented in national guidelines and budgets; child-friendly drug formulations for MDR-TB treatment are insufficiently available in 57% of countries, and 32% of countries reported paediatric drug stock-outs. The novel drugs, bedaquiline and delamanid, are accessible by respectively 80% and 60% of respondent countries. Respondents were asked how many children were diagnosed with MDR-TB in 2019, and a comparison of this number to modelled estimates of incidence (to identify the case detection gap) and WHO notifications (to identify the case reporting gap) showed substantial differences in both comparisons.
CONCLUSIONS: Better representation of this patient group in guidelines and budgets, greater access to drugs and improved reporting are essential to reach TB elimination in this Region.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 International Union Against Tuberculosis and Lung Disease. This is an author-produced version of a paper subsequently published in International Journal of Tuberculosis and Lung Disease. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Adolescent; Antitubercular Agents; Asia; Europe; Humans; Tuberculosis, Multidrug-Resistant; World Health Organization |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Funding Information: | Funder Grant number Medical Research Council MR/P022081/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 May 2022 12:59 |
Last Modified: | 01 Nov 2022 01:16 |
Status: | Published |
Publisher: | International Union Against Tuberculosis and Lung Disease |
Refereed: | Yes |
Identification Number: | 10.5588/ijtld.21.0541 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:186824 |