Hodge, F, Bajuszova, V and Van Oosten-Hawle, P orcid.org/0000-0002-5713-6457 (2022) The Intestine as a Lifespan- and Proteostasis-Promoting Signaling Tissue. Frontiers in Aging, 3. 897741. ISSN 1663-4365
Abstract
In multicellular organisms such as Caenorhabditis elegans, cellular stress stimuli and responses are communicated between tissues to promote organismal health- and lifespan. The nervous system is the predominant regulator of cell nonautonomous proteostasis that orchestrates systemic stress responses to integrate both internal and external stimuli. This review highlights the role of the intestine in mediating cell nonautonomous stress responses and explores recent findings that suggest a central role for the intestine to regulate organismal proteostasis. As a tissue that receives and further transduces signals from the nervous system in response to dietary restriction, heat- and oxidative stress, and hypoxia, we explore evidence suggesting the intestine is a key regulatory organ itself. From the perspective of naturally occurring stressors such as dietary restriction and pathogen infection we highlight how the intestine can function as a key regulator of organismal proteostasis by integrating insulin/IGF-like signaling, miRNA-, neuropeptide- and metabolic signaling to alter distal tissue functions in promoting survival, health- and lifespan.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 Hodge, Bajuszova and van Oosten-Hawle. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
Keywords: | intercellular signaling, intestine, cell-nonautonomous, proteostasis, C. elegans, stress, organismal aging, neurons |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Funding Information: | Funder Grant number NC3Rs NC/T002018/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 May 2022 13:00 |
Last Modified: | 25 Jun 2023 22:58 |
Status: | Published |
Publisher: | Frontiers Media |
Identification Number: | 10.3389/fragi.2022.897741 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:186715 |