Telisinghe, L., Shaweno, D., Hayes, R.J. et al. (2 more authors) (2021) The effect of systematic screening of the general population on TB case notification rates. The International Journal of Tuberculosis and Lung Disease, 25 (12). pp. 964-973. ISSN 1027-3719
Abstract
BACKGROUND: Understanding how TB case notification rates (TB-CNR) change with TB screening and their association with underlying TB incidence/prevalence could inform how they are best used to monitor screening impact.
METHODS: We undertook a systematic review to identify articles published between 1 January 1980 and 13 April 2020 on TB-CNR trends associated with TB screening in the general-population. Using a simple compartmental TB transmission model, we modelled TB-CNRs, incidence and prevalence dynamics during 5 years of screening.
RESULTS: Of 27,282 articles, seven before/after studies were eligible. Two involved population-wide screening, while five used targeted screening. The data suggest screening was associated with initial increases in TB-CNRs. Increases were greatest with population-wide screening, where screening identified a large proportion of notified people with TB. Only one study reported on sustained screening; TB-CNR trends were compatible with model simulations. Model simulations always showed a peak in TB-CNRs with screening. Following the peak, TB-CNRs declined but were typically sustained above baseline during the intervention. Incidence and prevalence decreased during the intervention; the relative decline in incidence was smaller than the decline in prevalence.
CONCLUSIONS: Published data on TB-CNR trends with TB screening are limited. These data are needed to identify generalisable patterns and enable method development for inferring underlying TB incidence/prevalence from TB-CNR trends.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Union. This is an author-produced version of a paper subsequently published in International Journal of Tuberculosis and Lung Disease. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Communicable Disease Control; Disease Notification; Humans; Incidence; Mass Screening; Prevalence; Tuberculosis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Funding Information: | Funder Grant number Medical Research Council MR/P022081/1 European & Developing Countries Clinical Trials Partnership RIA2016S-1632 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 11 May 2022 09:23 |
Last Modified: | 01 Jun 2022 00:39 |
Status: | Published |
Publisher: | International Union Against Tuberculosis and Lung Disease |
Refereed: | Yes |
Identification Number: | 10.5588/ijtld.21.0328 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:186662 |