Peace, A., Pinna, V., Timmen, F. et al. (5 more authors) (2020) Role of blood pressure in mediating carotid artery dilation in response to sympathetic stimulation in healthy, middle-aged individuals. American Journal of Hypertension, 33 (2). pp. 146-153. ISSN 0895-7061
Abstract
Objectives
Carotid artery diameter responses to sympathetic stimulation, i.e., carotid artery reactivity (CAR), represent a novel test of vascular health and relates to cardiovascular disease (CVD)/risk. This study aims to understand the relationship between the increase in blood pressure and carotid artery diameter response during the CAR-test in healthy, middle-aged men.
Methods
Sample consisted of 40 normotensive men (aged 31–59 years) with no history of CVD of currently taking medication. Noninvasive ultrasound was used to measure carotid artery diameter during the cold pressor test (CPT), with CAR% being calculated as the relative change from baseline (%). Mean arterial pressure (MAP) was measured with beat-to-beat blood pressure recording.
Results
CAR% was 4.4 ± 5.4%, peaking at 92 ± 43 seconds. MAP increased from 88 ± 9 mmHg to 110 ± 15 mmHg, peaked at 112 ± 38 seconds, which was significantly later than the diameter peak (P = 0.04). The correlation between resting MAP and CAR% was weak (r = 0.209 P = 0.197). Tertiles based on resting MAP or MAP-increase revealed no significant differences between groups in subject characteristics including age, body mass index, or CAR% (all P > 0.05). Subgroup analysis of individuals with carotid constriction (n = 6) vs. dilation (n = 34), revealed no significant difference in resting MAP or increase in MAP (P = 0.209 and 0.272, respectively).
Conclusion
Our data suggest that the characteristic increase in MAP during the CPT does not mediate carotid artery vasomotion.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 American Journal of Hypertension, Ltd. |
Keywords: | blood pressure; cardiovascular risk; carotid artery reactivity test; cold pressor test; coronary arteries; endothelial function; hypertension; Adult; Arterial Pressure; Carotid Artery, Common; Cold Temperature; Healthy Volunteers; Humans; Male; Middle Aged; Sympathetic Nervous System; Time Factors; Vasodilation |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 09 May 2022 13:00 |
Last Modified: | 09 May 2022 13:00 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Refereed: | Yes |
Identification Number: | 10.1093/ajh/hpz159 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:186511 |