Caliskan, Neva and Hill, Chris H orcid.org/0000-0001-7037-0611 (2022) Insights from structural studies of the cardiovirus 2A protein. Bioscience Reports. BSR20210406. ISSN 0144-8463
Abstract
Cardioviruses are single-stranded RNA viruses of the family Picornaviridae. In addition to being the first example of internal ribosome entry site (IRES) utilization, cardioviruses also employ a series of alternative translation strategies, such as Stop-Go translation and programmed ribosome frameshifting. Here, we focus on cardiovirus 2A protein, which is not only a primary virulence factor, but also exerts crucial regulatory functions during translation, including activation of viral ribosome frameshifting and inhibition of host cap-dependent translation. Only recently, biochemical and structural studies have allowed us to close the gaps in our knowledge of how cardiovirus 2A is able to act in diverse translation-related processes as a novel RNA-binding protein. This review will summarize these findings, which ultimately may lead to the discovery of other RNA-mediated gene expression strategies across a broad range of RNA viruses.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). |
Keywords: | Cardiovirus/genetics,Internal Ribosome Entry Sites/genetics,Viral Proteins/genetics |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 21 Apr 2022 08:50 |
Last Modified: | 31 Dec 2024 00:13 |
Published Version: | https://doi.org/10.1042/BSR20210406 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1042/BSR20210406 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:185954 |
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Filename: bsr_2021_0406c.pdf
Description: Insights from structural studies of the cardiovirus 2A protein
Licence: CC-BY 2.5