Speers, L.J., Schmidt, R. orcid.org/0000-0002-2474-3744 and Bilkey, D.K. (2022) Aberrant phase precession of lateral septal cells in a maternal immune activation model of schizophrenia risk may disrupt the integration of location with reward. Journal of Neuroscience, 42 (20). pp. 4187-4201. ISSN 0270-6474
Abstract
Spatial memory and reward processing are known to be disrupted in schizophrenia. Since the lateral septum (LS) may play an important role in the integration of location and reward, we examined the effect of maternal immune activation (MIA), a known schizophrenia risk factor, on spatial representation in the rat LS. In support of a previous study, we found that spatial location is represented as a phase code in the rostral LS of adult male rats, so that LS cell spiking shifts systematically against the phase of the hippocampal, theta-frequency, local field potential (LFP) as an animal moves along a track towards a reward (phase precession). Whereas shallow precession slopes were observed in control (CTL) group cells, they were steeper in the MIA animals, such that firing frequently precessed across several theta cycles as the animal moved along the length of the apparatus, with subsequent ambiguity in the phase representation of location. Furthermore, an analysis of the phase trajectories of the CTL group cells revealed that the population tended to converge towards a common firing phase as the animal approached the reward location. This suggested that phase coding in these cells might signal both reward location and the distance to reward. By comparison the degree of phase convergence in the MIA-group cells was weak, and the region of peak convergence was distal to the reward location. These findings suggest that a schizophrenia risk factor disrupts the phase-based encoding of location-reward relationships in the LS, potentially smearing reward representations across space.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 the authors. This is an author-produced version of a paper subsequently published in Journal of Neuroscience. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Apr 2022 13:43 |
Last Modified: | 10 Feb 2023 15:19 |
Status: | Published |
Publisher: | Society for Neuroscience |
Refereed: | Yes |
Identification Number: | 10.1523/JNEUROSCI.0039-22.2022 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:185857 |