Liu, X., Zhao, J., Qiu, G. et al. (4 more authors) (2022) Biological activities of some natural compounds and their cytotoxicity studies against breast and prostate cancer cell lines and anti-COVID19 studies. Journal of Oleo Science, 71 (4). ess21275. pp. 587-597. ISSN 1345-8957
Abstract
In this study, we investigated the inhibition effects of matairesinol, pregnanolone, hamamelitannin, secoisolariciresinol, and secoisolariciresinol diglicoside compounds on HMG-CoA reductase and urease enzymes. We have obtained results for the HMG-CoA reductase enzyme at the millimolar level, and for the urease enzyme at the micromolar level. Molecular docking calculations were made for their biological activities were compared. In docking calculations, proteins of experimentally used enzymes, activities of SARS-CoV-2 virus against RNA-dependent RNA polymerase (RdRp) protein, and anti-oxidant protein were compared. Then, ADME/T calculations were made to use the molecules as drugs. Cytotoxicity potential of these complexes against human breast and prostate cancers demonstrated that these compounds had good cytotoxic effects. There is growing attention to phenolic molecules and their presumed role in avoiding diverse degenerative diseases, such as cardiovascular and cancer diseases.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2022 by Japan Oil Chemists' Society. This article is licensed under a Creative Commons [Attribution 4.0 International] license. https://creativecommons.org/licenses/by/4.0/ |
Keywords: | phenolic compounds; cytotoxicity; molecular docking; enzyme inhibition; COVID19 |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Molecular Biology and Biotechnology (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Apr 2022 11:07 |
Last Modified: | 25 Apr 2022 11:07 |
Status: | Published |
Publisher: | Japan Oil Chemists' Society |
Refereed: | Yes |
Identification Number: | 10.5650/jos.ess21275 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:185842 |