Larvin, H orcid.org/0000-0001-7263-4182, Kang, J orcid.org/0000-0002-2770-1099, Aggarwal, V orcid.org/0000-0003-0838-9682 et al. (2 more authors) (2022) The additive effect of periodontitis with hypertension on risk of systemic disease and mortality. Journal of Periodontology, 93 (7). pp. 1024-1035. ISSN 0303-6979
Abstract
Aims
Recent evidence suggests that periodontitis causes hypertension, which is a precursor to development of other systemic diseases. The aim of this study was to examine the effect of hypertension and periodontitis on the risk of subsequent systemic disease.
Materials and Methods
This longitudinal cohort study included 244,393 UK Biobank participants who were free of systemic disease other than hypertension at baseline. Self-reported responses of painful gums or loose teeth were surrogates for periodontitis. Hypertensives were identified by clinical diagnosis, or elevated blood pressure (> = 140/90 mmHg). Systemic diseases including cancer, cardiovascular disease and diabetes were identified from linked diagnostic codes. Multivariable Cox proportional hazard models were used to quantify the risk of systemic diseases and all-cause mortality, stratified by hypertensive and periodontitis status.
Results
The average age of the study population was 55.4 (standard deviation[SD:] 8.1) years, and 130,220 (53.3%) participants were female. At baseline, 131,566 (53.8%) participants were hypertensive and 4.5% reported periodontitis. The incidence rates of all systemic diseases were higher in hypertensive than non-hypertensive participants of the same periodontitis status. In hypertensives, an additive effect was observed for periodontitis on the risks of cardiovascular disease (adjusted hazard ratio[HR]: 1.35, 95% confidence interval[CI]: 1.21-1.53) and respiratory disease (HR: 1.11, 95% CI: 0.95-1.30) compared to hypertensive healthy controls.
Conclusion(s)
Hypertensives with periodontitis have exacerbated risks of several systemic diseases. Future interventional studies should consider the effect of periodontal treatment on systemic outcomes in targeted hypertensive populations.
Metadata
Item Type: | Article |
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Authors/Creators: | |
Copyright, Publisher and Additional Information: | © 2022 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | hypertension; mortality; noncommunicable diseases; oral health; periodontitis; risk factors |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Applied Health and Clinical Translation (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Surgery (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 Apr 2022 11:07 |
Last Modified: | 25 Jun 2023 22:57 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/JPER.21-0621 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:185806 |