Jia, X, Gao, C, Wang, X et al. (2 more authors) (2022) Differential regulation by mechanical stretch of the expressions of large-conductance Ca2+-activated K+ channel and L-type voltage-dependent Ca2+ channel in rat uterine smooth muscle cells. Journal of Membrane Biology, 255 (2-3). pp. 357-361. ISSN 0022-2631
Abstract
Large-conductance Ca2+-activated K+ (BKCa) channel and L-type voltage-dependent Ca2+ channel (L-VDCC) play important roles in regulating uterine contractility. The uterus stretch, occurring during pregnancy, is a critical factor to trigger uterine contraction. However, how mechanical stimuli impact the two channels remains unknown. Here we investigated the effects of exposure to mechanical stretches with varying magnitudes and durations on expressions of the two channels in rat uterine smooth muscle cells. Our results show that stretch down-regulates the BKCa channel expression but upregulates the L-VDCC expression. These findings are helpful to better understand the roles of L-VDCC and BKCa channel in stretch-triggered uterine contraction.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. This is an author produced version of an article published in Journal of Membrane Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | BKCa channel; L-VDCC; Stretch; Uterine smooth muscle cell |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Mar 2022 13:53 |
Last Modified: | 23 Mar 2023 01:13 |
Status: | Published |
Publisher: | Springer |
Identification Number: | 10.1007/s00232-022-00226-0 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:185078 |