Karakonstantis, S., Ioannou, P. and Kritsotakis, E. orcid.org/0000-0002-9526-3852 (2022) Co-isolates of Acinetobacter baumannii complex in polymicrobial infections: a meta-analysis. Access Microbiology, 4 (5). 000348. ISSN 2516-8290
Abstract
Background: Acinetobacter baumannii complex (ABC) infections are commonly polymicrobial. Examining which pathogens are most commonly co-isolated with ABC is an important first step for assessing disease potential due to pathogen-pathogen interactions.
Methods: Based on a systematic search of PubMed, Scopus and CENTRAL, we estimated percent proportions of co-isolates in polymicrobial pulmonary and bloodstream ABC infections using random-effects meta-analysis.
Results: 28 eligible studies were analyzed reporting 575 polymicrobial bloodstream and 290 polymicrobial pulmonary infections. Common co-isolates in pulmonary infections were P. aeruginosa (36%, 95% CI 24-49%, I2 71%), S. aureus (28%, 95% CI 19-38%, I2 44%) and Klebsiella spp (11%, 95% CI 6-20%, I2 56%), while the prevalence of other co-pathogens did not exceed 5%. Most common co-isolates in bloodstream infections were coagulase-negative Staphylococci (21%, 95% CI 12-34%, I2 84%), Enterococci (15%, 95% CI 9-26%, I2 73%), P. aeruginosa (12%, 95% CI 6-22%, I2 74%), Klebsiella spp (10%, 95% CI 6-16%, I2 42%), Enterobacter spp (10%, 95% CI 6-16%, I2 38%) and S. aureus (8%, 95% CI 4-15%, I2 58%).
Conclusion: The common co-isolation of certain pathogens (especially P. aeruginosa) with ABC suggests potential beneficial between-pathogen interactions, which may have treatment implications for polymicrobial infections and requires further study.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0) |
Keywords: | Acinetobacter; polymicrobial; Pseudomonas; pneumonia; bacteremia |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Health and Related Research (Sheffield) > ScHARR - Sheffield Centre for Health and Related Research |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 25 Mar 2022 14:07 |
Last Modified: | 10 May 2022 15:31 |
Status: | Published |
Publisher: | Microbiology Society |
Refereed: | Yes |
Identification Number: | 10.1099/acmi.0.000348 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:184991 |