Shepelytskyi, Y., Grynko, V., Rao, M.R. et al. (4 more authors) (2022) Hyperpolarized 129Xe imaging of the brain : achievements and future challenges. Magnetic Resonance in Medicine, 88 (1). pp. 83-105. ISSN 0740-3194
Abstract
Hyperpolarized (HP) xenon-129 (129Xe) brain MRI is a promising imaging modality currently under extensive development. HP 129Xe is nontoxic, capable of dissolving in pulmonary blood, and is extremely sensitive to the local environment. After dissolution in the pulmonary blood, HP 129Xe travels with the blood flow to the brain and can be used for functional imaging such as perfusion imaging, hemodynamic response detection, and blood–brain barrier permeability assessment. HP 129Xe MRI imaging of the brain has been performed in animals, healthy human subjects, and in patients with Alzheimer's disease and stroke. In this review, the overall progress in the field of HP 129Xe brain imaging is discussed, along with various imaging approaches and pulse sequences used to optimize HP 129Xe brain MRI. In addition, current challenges and limitations of HP 129Xe brain imaging are discussed, as well as possible methods for their mitigation. Finally, potential pathways for further development are also discussed. HP 129Xe MRI of the brain has the potential to become a valuable novel perfusion imaging technique and has the potential to be used in the clinical setting in the future.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | HP 129Xe brain imaging; brain; hyperpolarized xenon-129; magnetic resonance imaging/spectroscopy; perfusion imaging |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Mar 2022 11:14 |
Last Modified: | 13 Feb 2023 16:31 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/mrm.29200 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:184683 |