Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, N, Gustafsson, NMS, Henriksson, M et al. (65 more authors) (2022) Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress. Nature Cancer, 3 (2). pp. 156-172.

Abstract

Metadata

Item Type: Article
Authors/Creators:
  • Bonagas, N
  • Gustafsson, NMS
  • Henriksson, M
  • Marttila, P
  • Gustafsson, R
  • Wiita, E
  • Borhade, S
  • Green, AC
  • Vallin, KSA
  • Sarno, A
  • Svensson, R
  • Göktürk, C
  • Pham, T
  • Jemth, A-S
  • Loseva, O
  • Cookson, V
  • Kiweler, N
  • Sandberg, L
  • Rasti, A
  • Unterlass, JE
  • Haraldsson, M
  • Andersson, Y
  • Scaletti, ER
  • Bengtsson, C
  • Paulin, CBJ
  • Sanjiv, K
  • Abdurakhmanov, E
  • Pudelko, L
  • Kunz, B
  • Desroses, M
  • Iliev, P
  • Färnegårdh, K
  • Krämer, A
  • Garg, N
  • Michel, M
  • Häggblad, S
  • Jarvius, M
  • Kalderén, C
  • Jensen, AB
  • Almlöf, I
  • Karsten, S
  • Zhang, SM
  • Häggblad, M
  • Eriksson, A
  • Liu, J
  • Glinghammar, B
  • Nekhotiaeva, N
  • Klingegård, F
  • Koolmeister, T
  • Martens, U
  • Llona-Minguez, S
  • Moulson, R
  • Nordström, H
  • Parrow, V
  • Dahllund, L
  • Sjöberg, B
  • Vargas, IL
  • Vo, DD
  • Wannberg, J
  • Knapp, S
  • Krokan, HE
  • Arvidsson, PI
  • Scobie, M
  • Meiser, J
  • Stenmark, P
  • Berglund, UW
  • Homan, EJ
  • Helleday, T ORCID logo https://orcid.org/0000-0002-7384-092X
Copyright, Publisher and Additional Information:

© 2022 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Dates:
  • Published: February 2022
  • Published (online): 28 February 2022
  • Accepted: 10 January 2022
Institution: The University of Sheffield
Academic Units: The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Depositing User: Symplectic Sheffield
Date Deposited: 07 Mar 2022 08:43
Last Modified: 07 Mar 2022 08:43
Status: Published
Publisher: Springer Nature
Refereed: Yes
Identification Number: 10.1038/s43018-022-00331-y
Related URLs:
Open Archives Initiative ID (OAI ID):

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