Tadimalla, S., Wilson, D.J., Shelley, D. et al. (8 more authors) (2022) Bias, repeatability and reproducibility of liver T1 mapping with variable flip angles. Journal of Magnetic Resonance Imaging, 56 (4). pp. 1042-1052. ISSN 1053-1807
Abstract
Background
Three-dimensional variable flip angle (VFA) methods are commonly used for T1 mapping of the liver, but there is no data on the accuracy, repeatability, and reproducibility of this technique in this organ in a multivendor setting.
Purpose
To measure bias, repeatability, and reproducibility of VFA T1 mapping in the liver.
Study Type
Prospective observational.
Population
Eight healthy volunteers, four women, with no known liver disease.
Field Strength/Sequence
1.5-T and 3.0-T; three-dimensional steady-state spoiled gradient echo with VFAs; Look-Locker.
Assessment
Traveling volunteers were scanned twice each (30 minutes to 3 months apart) on six MRI scanners from three vendors (GE Healthcare, Philips Medical Systems, and Siemens Healthineers) at two field strengths. The maximum period between the first and last scans among all volunteers was 9 months. Volunteers were instructed to abstain from alcohol intake for at least 72 hours prior to each scan and avoid high cholesterol foods on the day of the scan.
Statistical Tests
Repeated measures ANOVA, Student t-test, Levene's test of variances, and 95% significance level. The percent error relative to literature liver T1 in healthy volunteers was used to assess bias. The relative error (RE) due to intrascanner and interscanner variation in T1 measurements was used to assess repeatability and reproducibility.
Results
The 95% confidence interval (CI) on the mean bias and mean repeatability RE of VFA T1 in the healthy liver was 34 ± 6% and 10 ± 3%, respectively. The 95% CI on the mean reproducibility RE at 1.5 T and 3.0 T was 29 ± 7% and 25 ± 4%, respectively.
Data Conclusion
Bias, repeatability, and reproducibility of VFA T1 mapping in the liver in a multivendor setting are similar to those reported for breast, prostate, and brain.
Level of Evidence
1
Technical Efficacy Stage
1
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/). |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) |
Funding Information: | Funder Grant number European Commission - HORIZON 2020 116106 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Mar 2022 14:34 |
Last Modified: | 17 Nov 2022 15:08 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1002/jmri.28127 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:184412 |