Townley, C, McMurray, L, Marsden, SP orcid.org/0000-0002-2723-8954 et al. (1 more author) (2022) A unified “top-down” approach for the synthesis of diverse lead-like molecular scaffolds. Bioorganic and Medicinal Chemistry Letters, 62. 128631. ISSN 0960-894X
Abstract
A “top-down” synthetic approach enabled the step-efficient synthesis of 21 diverse novel molecular scaffolds. The scaffolds were derived from four complex intermediates that had been prepared using cycloaddition chemistry. Scaffold-hopping of these intermediates was achieved through attachment of an additional ring, ring cleavage, ring expansion and/or ring fusion. It was shown that the resulting scaffolds could be decorated to yield diverse lead-like screening compounds.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 Elsevier Ltd. All rights reserved. This is an author produced version of an article, published in Bioorganic and Medicinal Chemistry Letters. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Molecular diversity; Molecular scaffolds; Screening compounds |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 04 Mar 2022 14:29 |
Last Modified: | 16 Feb 2023 01:13 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.bmcl.2022.128631 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:184225 |