WO2018211275 - COMPOUNDS

Abstract

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein R1, R2, R3, R4, R5, R6, R8, R9, X, X1, X2, X3, L1 and n are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds;and intermediates useful in the preparation of the compounds.

Metadata

Item Type:	Patent
Authors/Creators:	Richards, G. https://orcid.org/0000-0001-7984-6882 Skerry, T.M. Harrity, J.P.A. Zirimwabagabo, J.-O. Tozer, M.J. Gibson, K.R. Porter, R.A. Blaney, P.M. Glossop, P.A.
Copyright, Publisher and Additional Information:	Copyright on patents filed since 1969 lies with the applicants. There is an exemption allowing patent contents to be reproduced for the purpose of disseminating information, but other uses are prohibited without a license from the copyright holder.
Dates:	Published: 22 November 2018 Submitted: 17 May 2017 Filed: 16 May 2018
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Funding Information:	Funder Grant number The Wellcome Trust 101790/Z/13/Z
Depositing User:	Symplectic Sheffield
Date Deposited:	02 Feb 2022 09:33
Last Modified:	02 Feb 2022 09:33
Published Version:	https://patentscope.wipo.int/search/en/detail.jsf?...
Status:	Published
Identification Number:	WO2018/211275Al
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:183172

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WO2018211275 - COMPOUNDS

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