Gamper, N orcid.org/0000-0001-5806-0207 and Shah, S (2022) Inferiority complex: why do sensory ion channels multimerize? Biochemical Society Transactions, 50 (1). pp. 213-222. ISSN 0300-5127
Abstract
Peripheral somatosensory nerves are equipped with versatile molecular sensors which respond to acute changes in the physical environment. Most of these sensors are ion channels that, when activated, depolarize the sensory nerve terminal causing it to generate action potentials, which is the first step in generation of most somatic sensations, including pain. The activation and inactivation of sensory ion channels is tightly regulated and modulated by a variety of mechanisms. Amongst such mechanisms is the regulation of sensory ion channel activity via direct molecular interactions with other proteins in multi-protein complexes at the plasma membrane of sensory nerve terminals. In this brief review, we will consider several examples of such complexes formed around a prototypic sensory receptor, transient receptor potential vanilloid type 1 (TRPV1). We will also discuss some inherent conceptual difficulties arising from the multitude of reported complexes.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2022 The Author(s). This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) |
Keywords: | G-protein-coupled receptors, nociception, pain, sensory neurons, TRPV1 |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Funding Information: | Funder Grant number MRC (Medical Research Council) Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 31 Jan 2022 10:40 |
Last Modified: | 10 May 2022 08:13 |
Status: | Published |
Publisher: | Portland Press |
Identification Number: | 10.1042/BST20211002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:182882 |