Berry, S.S. and Jones, S. orcid.org/0000-0001-8043-7998 (2021) Current applications of kinetic resolution in the asymmetric synthesis of substituted pyrrolidines. Organic & Biomolecular Chemistry, 19 (48). pp. 10493-10515. ISSN 1477-0520
Abstract
Chiral substituted pyrrolidines are key elements in various biologically active molecules and are therefore valuable synthetic targets. One traditional method towards enantiomerically pure compounds is the application of kinetic resolution. In this review, current KR methodology used in the synthesis of substituted pyrrolidines is surveyed, including enzymatic methods, cycloadditions and reduction of ketones.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Authors. Organic & Biomolecular Chemistry published by The Royal Society of Chemistry. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/). |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Chemistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 14 Jan 2022 08:46 |
Last Modified: | 14 Jan 2022 08:46 |
Status: | Published |
Publisher: | Royal Society of Chemistry (RSC) |
Refereed: | Yes |
Identification Number: | 10.1039/d1ob01943k |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:182540 |