Encabo, Hector Huerga, Grey, William George orcid.org/0000-0001-8209-5645, Garcia-Albornoz, Manuel et al. (8 more authors) (2021) Human erythroid progenitors are directly infected by SARS-CoV-2:Implications for hypoxia and emerging haematopoiesis/erythropoiesis in COVID-19. Stem Cell Reports. pp. 428-436. ISSN 2213-6711
Abstract
We document here that intensive care COVID-19 patients suffer a profound decline in hemoglobin levels but show an increase of circulating nucleated red cells, suggesting that SARS-CoV-2 infection either directly or indirectly induces stress erythropoiesis. We show that ACE2 expression peaks during erythropoiesis and renders erythroid progenitors vulnerable to infection by SARS-CoV-2. Early erythroid progenitors, defined as CD34−CD117+CD71+CD235a−, show the highest levels of ACE2 and constitute the primary target cell to be infected during erythropoiesis. SARS-CoV-2 causes the expansion of colony formation by erythroid progenitors and can be detected in these cells after 2 weeks of the initial infection. Our findings constitute the first report of SARS-CoV-2 infectivity in erythroid progenitor cells and can contribute to understanding both the clinical symptoms of severe COVID-19 patients and how the virus can spread through the circulation to produce local inflammation in tissues, including the bone marrow.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2021 The Author(s). |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 13 Jan 2022 16:10 |
Last Modified: | 27 Nov 2024 00:42 |
Published Version: | https://doi.org/10.1016/j.stemcr.2021.02.001 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.stemcr.2021.02.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:182526 |