Pedro, RDO, Pereira, S, Goycoolea, FM et al. (2 more authors) (2018) Self-aggregated nanoparticles of N-dodecyl,N′-glycidyl(chitosan) as pH-responsive drug delivery systems for quercetin. Journal of Applied Polymer Science, 135 (2). 45678. ISSN 0021-8995
Abstract
In this study, pH-responsive amphiphilic chitosan (CS) nanoparticles were used to encapsulate quercetin (QCT) for sustained release in cancer therapy. The novel CS derivatives were obtained by synthesis with 2,3-epoxy-1-propanol, also known as glycidol, followed by acylation with dodecyl aldehyde. Characterization was performed by spectroscopic, viscosimetric, and size-determination methods. Critical aggregation concentration, morphology, entrapment efficiency, drug release profile, cytotoxicity, and hemocompatibility studies were also carried out. The average size distribution of the self-assembling nanoparticles measured by dynamic light scattering ranged from 140 to 300 nm. In vitro QCT release and Korsmeyer–Peppas model indicated that pH had a major role in drug release. Cytotoxicity assessments indicated that the nanoparticles were non-cytotoxic. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay further revealed that QCT-loaded nanoparticles could inhibit MCF-7 cell growth. In vitro erythrocyte-induced hemolysis indicated the good hemocompatibility of the nanoparticles. These results suggest that the synthesized copolymers might be potential carriers for hydrophobic drugs in cancer therapy.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2017 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Pedro, R. . O., Pereira, S., Goycoolea, F. M., Schmitt, C. C. and Neumann, M. G. (2017), Self-aggregated nanoparticles of N-dodecyl,N′-glycidyl(chitosan) as pH-responsive drug delivery systems for quercetin. J. Appl. Polym. Sci., 135, 45678 doi: 10.1002/app.45678; which has been published in final form at https://doi.org/10.1002/app.45678. This article may be used for non-commercial purposes in accordance with the Wiley Terms and Conditions for Self-Archiving. |
Keywords: | biopolymers and renewable polymers; drug delivery systems; nanocrystals; nanoparticles; nanowires |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 30 Nov 2021 15:33 |
Last Modified: | 09 May 2022 16:44 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/app.45678 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:181020 |