Higgs, PL, Appleton, JL, Turnbull, WB orcid.org/0000-0002-7352-0360 et al. (1 more author) (2021) Exploiting the Structural Metamorphosis of Polymers to ‘Wrap’ Micron‐Sized Spherical Objects. Chemistry: A European Journal, 27 (70). pp. 17647-17654. ISSN 0947-6539
Abstract
There is growing interest in developing methods to ‘wrap’ nano- and micron-sized biological objects within films that may offer protection, enhance their stability or improve performance. We describe the successful ‘wrapping’ of lectin-decorated microspheres, which serve as appealing model micron-sized objects, within cross-linked polymer film. This approach utilizes polymer chains able to undergo a structural metamorphosis, from being intramolecularly cross-linked to intermolecularly cross-linked, a process that is triggered by polymer concentration upon the particle surface. Experiments demonstrate that both complementary molecular recognition and the dynamic covalent nature of the crosslinker are required for successful ‘wrapping’ to occur. This work is significant as it suggests that nano- and micron-sized biological objects such as virus-like particles, bacteria or mammalian cells—all of which may benefit from additional environmental protection or stabilization in emerging applications—may also be ‘wrapped’ by this approach.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Wiley-VCH GmbH. This is the peer reviewed version of the following article: Higgs, PL, Appleton, JL, Turnbull, WB et al. (1 more author) (2021) Exploiting the Structural Metamorphosis of Polymers to ‘Wrap’ Micron‐Sized Spherical Objects. Chemistry: A European Journal, 27 (70). pp. 17647-17654. ISSN 0947-6539, which has been published in final form at https://doi.org/10.1002/chem.202103216. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | adaptive materials; dynamic covalent chemistry; polymer films; polymer wrapper; structural metamorphosis; supramolecular chemistry; adaptive materials dynamic covalent chemistry polymer films polymer wrapper structural metamorphosis supramolecular chemistry |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Organic Chemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 25 Nov 2021 12:47 |
Last Modified: | 19 Oct 2022 00:17 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/chem.202103216 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:180696 |