Deng, X, Hasan, A, Elsharkawy, S et al. (12 more authors) (2021) Topographically guided hierarchical mineralization. Materials Today Bio, 11. 100119. ISSN 2590-0064
Abstract
Material platforms based on interaction between organic and inorganic phases offer enormous potential to develop materials that can recreate the structural and functional properties of biological systems. However, the capability of organic-mediated mineralizing strategies to guide mineralization with spatial control remains a major limitation. Here, we report on the integration of a protein-based mineralizing matrix with surface topographies to grow spatially guided mineralized structures. We reveal how well-defined geometrical spaces defined within the organic matrix by the surface topographies can trigger subtle changes in single nanocrystal co-alignment, which are then translated to drastic changes in mineralization at the microscale and macroscale. Furthermore, through systematic modifications of the surface topographies, we demonstrate the possibility of selectively guiding the growth of hierarchically mineralized structures. We foresee that the capacity to direct the anisotropic growth of such structures would have important implications in the design of biomineralizing synthetic materials to repair or regenerate hard tissues.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 The Author(s). This is an open access article under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) |
Keywords: | Fluorapatite; Protein-based biomineralization; Hierarchical mineralization; Elastin-like recombinamer; Bone; Dental enamel; Crystallization; Surface topographies |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Nov 2021 14:35 |
Last Modified: | 26 Nov 2021 14:35 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.mtbio.2021.100119 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:180543 |
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