Sex‐based differences in severity and mortality in COVID‐19

Abstract

The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus pandemics such as SARS-CoV and MERS-CoV, and viral infections in general. Here, we discuss the sex-disaggregated epidemiological data for COVID-19 and highlight underlying differences that may explain the sexual dimorphism to help inform risk stratification strategies and therapeutic options.

Metadata

Item Type:	Article
Authors/Creators:	Alwani, M. Yassin, A. Al‐Zoubi, R.M. Aboumarzouk, O.M. Nettleship, J. Kelly, D. AL‐Qudimat, A.R. Shabsigh, R.
Copyright, Publisher and Additional Information:	© 2021 The Authors. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited (http://creativecommons.org/licenses/by/4.0/).
Keywords:	COVID-19; dimorphism; sex
Dates:	Published: 13 November 2021 Published (online): 1 March 2021 Accepted: 20 January 2021
Institution:	The University of Sheffield
Academic Units:	The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield)
Depositing User:	Symplectic Sheffield
Date Deposited:	15 Nov 2021 14:39
Last Modified:	17 Nov 2021 08:45
Status:	Published
Publisher:	Wiley
Refereed:	Yes
Identification Number:	10.1002/rmv.2223
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:180430

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Sex‐based differences in severity and mortality in COVID‐19

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