Treweek, Shaun, Bevan, Simon, Bower, Peter et al. (24 more authors) (2020) Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed. Trials. ISSN 1745-6215
Abstract
The evidence base available to trialists to support trial process decisions—e.g. how best to recruit and retain participants, how to collect data or how to share the results with participants—is thin. One way to fill gaps in evidence is to run Studies Within A Trial, or SWATs. These are self-contained research studies embedded within a host trial that aim to evaluate or explore alternative ways of delivering or organising a particular trial process. SWATs are increasingly being supported by funders and considered by trialists, especially in the UK and Ireland. At some point, increasing SWAT evidence will lead funders and trialists to ask: given the current body of evidence for a SWAT, do we need a further evaluation in another host trial? A framework for answering such a question is needed to avoid SWATs themselves contributing to research waste. This paper presents criteria on when enough evidence is available for SWATs that use randomised allocation to compare different interventions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2020, The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 09 Nov 2021 12:10 |
Last Modified: | 16 Oct 2024 17:59 |
Published Version: | https://doi.org/10.1186/s13063-019-3980-5 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1186/s13063-019-3980-5 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:180239 |