Al-Taweel, F.B.H., Saliem, S.S., Abd, O.H. et al. (1 more author) (2021) Assessment of serum interleukin-1β and interleukin-6 levels in patients with chronic periodontitis and coronary heart disease. European Journal of General Dentistry, 10 (02). pp. 78-83. ISSN 2278-9626
Abstract
Objective: The aim of this study was to assess whether serum cytokine levels correlate with clinical periodontal parameters in health or disease.
Materials and Methods: Male subjects (40–60 years) with CP (n = 30), CP + CHD (n = 30), and healthy controls (n = 20) had plaque index (PLI), gingival index (GI), bleeding on probing, probing pocket depth (PPD), and clinical attachment level (CAL) evaluated. Serum IL-1β and IL-6 levels were quantified using enzyme-linked immunosorbent assay.
Results: PLI, GI, PPD, and CAL were significantly higher in patients with CP + CHD compared to those with CP. Serum levels of IL-1β and IL-6 were also significantly higher in CP + CHD compared to those with CP, with both groups also being significantly higher than controls. There was a strong correlation between IL-1β and PPD and CAL and between IL-6 and GI and CAL in the CP group and between IL-6 and GI and PPD in the CP + CHD group.
Conclusion: The results provide further evidence that periodontitis triggers systemic inflammation. Cytokine levels in patients with periodontitis may represent a useful screening tool to identify those at greater risk of cardiovascular events.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 European Journal of General Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Keywords: | interleukin-1β; interleukin-6; periodontitis; coronary heart disease |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 05 Nov 2021 08:42 |
Last Modified: | 05 Nov 2021 08:42 |
Status: | Published |
Publisher: | Georg Thieme Verlag KG |
Refereed: | Yes |
Identification Number: | 10.1055/s-0041-1732954 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:180062 |