Bon, RS orcid.org/0000-0003-1733-3680, Wright, DJ, Beech, DJ orcid.org/0000-0002-7683-9422 et al. (1 more author) (2022) Pharmacology of TRPC Channels and Its Potential in Cardiovascular and Metabolic Medicine. Annual Review of Pharmacology and Toxicology, 62. pp. 427-446. ISSN 0362-1642
Abstract
Transient receptor potential canonical (TRPC) proteins assemble to form homo- or heterotetrameric, nonselective cation channels permeable to K+, Na+, and Ca2+. TRPC channels are thought to act as complex integrators of physical and chemical environmental stimuli. Although the understanding of essential physiological roles of TRPC channels is incomplete, their implication in various pathological mechanisms and conditions of the nervous system, kidneys, and cardiovascular system in combination with the lack of major adverse effects of TRPC knockout or TRPC channel inhibition is driving the search of TRPC channel modulators as potential therapeutics. Here, we review the most promising small-molecule TRPC channel modulators, the understanding of their mode of action, and their potential in the study and treatment of cardiovascular and metabolic disease.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This is protected by copyright. All rights reserved. This is an author produced version of an article published in Annual Review of Pharmacology and Toxicology. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Specialist Science Education Dept (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 110044/Z/15/Z BBSRC (Biotechnology & Biological Sciences Research Council) BB/P020208/1 British Heart Foundation PG/19/2/34084 |
Depositing User: | Symplectic Publications |
Date Deposited: | 17 Nov 2021 12:53 |
Last Modified: | 09 Sep 2022 00:21 |
Status: | Published |
Publisher: | Annual Reviews |
Identification Number: | 10.1146/annurev-pharmtox-030121-122314 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:179852 |