Khokhar, K and Conaghan, PG orcid.org/0000-0002-3478-5665 (2021) Bone in osteoarthritis: imaging and interventions. Current Opinion in Rheumatology. ISSN 1040-8711
Abstract
Purpose of review
To review the recent literature on bone in osteoarthritis (OA), with a focus on imaging and intervention studies
Recent findings
Most studies focused on knee OA; hip and hand studies were uncommon. Bone shape studies demonstrated that shape changes precede radiographic OA, predict joint replacement, and have demonstrated high responsiveness. Novel quantitative 3D imaging markers (B-score) have better characterized OA severity, including preradiographic OA status. The addition of computerized tomography-derived 3D metrics has improved the prediction of hip joint replacement when compared to radiographs alone.
Recent studies of bisphosphonates for knee OA have reported no benefits on pain or bone marrow lesion (BML) size. A meta-analysis on Vitamin D supplementation in knee OA suggested minimal symptom improvement and no benefits on the structure. Cathepsin K inhibition demonstrated reduction in OA bone change progression, but with no symptom benefit. Studies of injections of bone substitutes into BMLs (subchondroplasty) have generally been small and potential benefits remain unclear.
Summary
Subchondral bone features are associated with pain, incidence and progression of OA. Recent studies have validated quantitative bone shape as a biomarker for OA trials. Trials of bone-targeted OA therapies have been disappointing although cathepsin K inhibition may slow structural progression.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2021 Wolters Kluwer Health, Inc. All rights reserved. This is an author produced version of a review published in Current Opinion in Rheumatology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | biomarker; bone marrow lesions; bone shape; osteoarthritis |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 Nov 2021 14:13 |
Last Modified: | 22 Oct 2022 00:13 |
Status: | Published online |
Publisher: | Lippincott, Williams & Wilkins |
Identification Number: | 10.1097/bor.0000000000000849 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:179797 |